Ginekologia i Poloznictwo
ISSN 1896-3315 e-ISSN 1898-0759

Rejuvenating the ovaries: A review of innovative strategies for fertility restoration


Abstract

Author(s): Julia Maria Marschollek*, Hubert Milosz Sawczuk, Marcin Piersiak, Maciej Pachana, Anna Tomasiewicz, Jan Zabierowski, Piotr Kukula, Maciej Ziomek

Modern women are delaying having children, which increases their risk of developing ovarian insufficiency. Over the course of her reproductive life, a woman's ability to procreate is mostly determined by the number of follicles in her ovaries and the quality of the oocytes that are produced within them. Advance age is a major risk factor for reducing the amount and quality of viable eggs. Thus, it is vitally critical to develop innovative methods for safely restoring ovarian function. Ovarian rejuvenation is a new term that has acquired popularity recently. This review will concentrate on knowledge gained in recent years regarding ovarian aging, potential ways of treatment, and extending the ovaries' lifespan. New treatments are being investigated, including stem cell therapies, mitochondrial enhancement therapy, and, most recently, PRP injections. In any case, further research is needed to determine the optimal dosages, minimize danger, and maximize the effectiveness of the interventions.