Department of Anesthesia, ICU and Pain Management, South Egypt Cancer Institute, SECI, Assiut University, Assiut, Egypt
Research
Retrospective cohort study on the efficacy of prophylactic tranexamic acid in reducing blood loss in elective cesarean delivery: A single-center analysis
Author(s): Khaled M. Alanwer*, Nehal Bassiouny, Mohamed Abdo, Mohamed Alshahat Elsayed Ali, Mohamed Mohamed Hegab and Bahaa G Mohamed
Background and aim: Prophylactic Tranexamic acid (TxA) shows promise in reducing postpartum hemorrhage. This study aimed to evaluate the effectiveness of routine prophylactic TxA in reducing blood loss during elective Cesarean Sections (CS) at a tertiary care center. Methods: This retrospective cohort study was conducted at Saudi German Hospital from May 2018 to April 2022, approved by ERC (004/2022). It included 600 women undergoing elective CS, divided into two groups: a TxA group (n=300, May 2020–April 2022) receiving 1g IV TxA and a control group (n=300, May 2018–April 2020) receiving none. The primary outcome was hemoglobin drop ≥ 2 g/dL. Secondary outcomes included estimated blood loss (EBL) and neonatal parameters. Statistical analysis utilized t-tests, chi-square, and multivariable regression. Results: Baseline characteristics were comparable. The TxA group demo.. Read More»