Abstract
Author(s): Belma Gözde Özdemir*, İkram Kerimoğlu, Rabia Can, Ahmet Bilgi, Çetin Çelik
Background/Aim: Brenner tumors are usually asymptomatic and are discovered incidentally. If symptomatic, there is abdominal distension, pelvic pain, and a mass sensation. On imaging, they appear as a mixture of solid and cystic components and are typically large. Tumor marker CA125 levels may be elevated in some patients; however, this is a nonspecific finding. This study aimed to present a single-center evaluation of the diagnosis, treatment, and follow-up of malignant Brenner tumors. Material/Methods: Data were collected from patients aged 18-90 who applied to the Department of Obstetrics and Gynecology at Selçuk University Faculty of Medicine between 2010 and 2024 and underwent surgery due to pelvic mass. Demographic and diagnostic methods, treatment principles, and patient processes were thoroughly analyzed. Results: A total of 21 patients were evaluated. Eighteen patients did not receive Chemotherapy (CT), and 20 patients did not receive Radiotherapy (RT). Taking into account age and additional diseases, 11 patients underwent hysterectomy and oophorectomy. It was found that 52.4% of the participants included in the study had hysterectomy bilateral Salpingo-oophorectomy, followed by Debulking with 28.6%; 42.9% had a diagnosis of pelvic mass; 95.2% did not receive KT; 95.2% did not receive RT; 55.6% had a diagnosis of Brenner and 25.0% had an additional disease of HT, followed by hypothyroidism with 15%. According to the table above, the average age of the participants was determined to be 65.52 ± 11.04. The average of ca125 was 92.19 ± 222.08; the average of CEA was 1.84 ± 0.88; the average of AFP was 3.69 ± 0.10; the average of ca19.9 was 16.31 ± 13.22, and the average of ca15.34 was 21.07 ± 16.49. According to the findings of the correlation analysis in the table above, there was a statistically significant, moderate, and positive relationship between the age of the participants and Ca125 (r=0.573, p<0.05). There was no statistically significant relationship between the age of the participants and CEA (r=-0.614). There was a statistically significant, high, and positive relationship between the age of the participants and AFP (r=1.000, p<0.01). Conclusion: Although they are rare tumor types, an individualized approach is essential, and persistent masses should be closely followed up, especially.