Abstract
Author(s): Lubna Amer Al-Anbari, Mufeda Ali Jwad, Muayad Sraibet Abbood, Amal Abdul Mahdi Kadhim and Hayder Ridha-Salman*
Background: Polycystic Ovary Syndrome (PCOS) is a common cause of infertility. The usual management of PCOS is Ovulation Induction (OI) before trying assisted reproductive technologies. A being safe treatment, Intrauterine Insemination (IUI) could benefit PCOS patients’ fertility.
Objective: The current research was aimed to evaluate the effect of Salvia officinalis extract on PCOS patients undergoing IUI.
Methods: Four hundred sixty- one PCOS women diagnosed according to Rotterdam criteria attended the Infertility Clinic of The High Institute for Infertility Diagnosis and Assisted Reproductive Technologies/Al-Nahrain University/ Baghdad/ Iraq, during the period from June 2020 to June 2024. The patients were grouped randomly into two groups (Group A) received 500 mg of oral Salvia officinalis leaf extract capsules for 8 weeks before IUI; (Group B) received placebo capsules for the same duration. Demographic parameters, baseline hormonal levels, ovarian stimulation characteristics, and pregnancy outcomes were analyzed and compared between the two groups. A total of 400 IUI cycles were included, 200 in each group.
Results: The statistical analysis showed no significant difference in demographic parameters or baseline hormonal levels between the groups. Regarding ovarian stimulation characteristics; number of dominant follicles, endometrial thickness, serum E2, were significantly higher in group A (p= 0.003, p= 0.008, p= 0.002) respectively. The clinical pregnancy rate, live birth rate of group A were significantly higher (p= 0.0274, p= 0.0274).
Conclusion: Salvia Officinalis extract can improve the clinical pregnancy rate, and live birth rate among an ovulatory PCOS patients undergoing IUI.