Department of Basic Sciences, Faculty of Dentistry, University of Babylon, Babylon, Iraq
Research
The potential of methotrexate-loaded nanoparticles to alleviate autoimmune arthritis in the clinical context of a urinary tract infection
Author(s): Zeinab Hameed Abbas*, Ali Ameer Hamzah, Saleem Abbas Ajzan, Shaima M. Alsabty, Zainab Ali Hussein and Saif M. Hassan
Background: Rheumatoid Arthritis (RA) is a progressive inflammatory illness marked by inflammation and overgrowth of the synovial membrane, leading to the creation of rheumatoid pannus.
Method: 125 urine samples and blood were obtained from individuals diagnosed with RA who sought medical attention at the general hospital in the province between the dates of 2 January and 14 February 2024. Blood sample was drawn for the purpose of conducting a series of immune tests, including those for IgG, IgM, IL-2, IL-4, IL-13, TNF-α, and TLR2 and TLR4. Vitro study employed a total of 50 rats, consisting 25 males and 25 females. The rats were randomly assigned to one of four groups, The sham group was supplied physiological saline (0.9%), whereas the control/induction group got an intradermal injection 100 μg of CII e.. Read More»