Department of Medicine, College of Medicine Jabir ibn Hayyan University for Medical and Pharmaceutical Sciences, Najaf, Iraq
 Research   
                                        
                                                                                The potential of methotrexate-loaded nanoparticles to alleviate autoimmune arthritis in the clinical context of a urinary tract infection 
                                                                                Author(s): Zeinab Hameed Abbas*, Ali Ameer Hamzah, Saleem Abbas Ajzan, Shaima M. Alsabty, Zainab Ali Hussein and Saif M. Hassan             
                                        
                                                                                
                                 Background: Rheumatoid  Arthritis (RA) is a progressive inflammatory illness marked by inflammation and  overgrowth of the synovial membrane, leading to the creation of rheumatoid  pannus. 
Method: 125  urine samples and blood were obtained from individuals diagnosed with RA who  sought medical attention at the general hospital in the province between the  dates of 2 January and 14 February 2024. Blood sample was drawn for the purpose  of conducting a series of immune tests, including those for IgG, IgM, IL-2,  IL-4, IL-13, TNF-α, and TLR2 and TLR4. Vitro study employed a total of 50 rats,  consisting 25 males and 25 females. The rats were randomly assigned to one of  four groups, The sham group was supplied physiological saline (0.9%), whereas  the control/induction group got an intradermal injection 100 μg of CII  e.. Read More»