Bilad Alrafidain University College, Diyala, Iraq
Research
Effect of iron overload on inhibin B synthesis in transfusion dependent Thalassemic women
Author(s): Dina A.A.Abdullah, Fatimah Kadhim Ibrahim AL-Mahdawi*, Mazin Razooqi Mohammed, Ammar Kadi, Marouane Chemek and Irina Potoroko
In women with thalassemia, particularly those with beta-thalassemia major, levels of inhibin B can be decreased, especially in those with significant iron overload, and there can be damage to the Gonads (testes in males, ovaries in females). This study was designed to determine inhibin B levels. In women with thalassemia undergoing regular blood transfusions, 40 female patients were included in this study was transfusion-dependent beta-thalassemia, with an age range of 18–20 years. All patients received blood transfusions at regular intervals (once/ month) to maintain a hemoglobin level of at least 10 gm/dl, all patients included in this study did not take iron Chelating therapy and have ferritin level >4000 µg/L. A hormone assay was done with hormones using the COBAS e411 test (from Roche, company). They used ELISA to test for Inhibin B and did a statistical ana.. Read More»