Ahmed Mohamed Abd El-Hay
Dr, Department of Obstetrics and Gynaecology, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Publications
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Research
Effect of anti-mullerian hormone in patients with polycystic ovarian syndrome on pregnancy rate in ICSI cycle
Author(s): Ahmed Mohamed Abd El-Hay*, Mohammed Salah Elsayed Elsokkary and Bassem Aly Islam
Background: Polycystic ovarian syndrome (PCOS) is the most frequent cause of anovulatory infertility and hyperandrogenism in young women. Women with this syndrome are characterized by an excessive number of small antral follicles (2–3 fold that of normal ovaries). Anti-Müllerian hormone (AMH), a member of the transforming growth factor-beta superfamily, it is mainly secreted in human ovary by the granulosa cells of ovarian early developing follicles. AMH is secreted inside preantral and early antral follicles <4 mm in diameter in granulosa cells. Its secretion decreases when the antral follicles begin to grow and stops when the follicles are larger 8 mm in diameter, or when atresia occurs. AMH levels are shown to be age-dependent, it is rarely detectable in new born baby girls and it reaches peaks after puberty and steadily declines with age u.. Read More»