Abstract
Author(s): Ahmed Sherif Abd El Hamid*, Abd El Megeed Ismail Abd El Megeed, Rawhia Elsayed Mohammed Elsayed, Ahmed Mahmoud Hussein
Background: During pregnancy, the CBC (complete blood count) can be used to predict placental invasion anomalies. Studies have suggested that cancer cell invasion shares some similarities with trophoblast invasion. Objective: To determine the prognostic role of CBC parameters for the Placenta Accreta Spectrum (PAS). Patients and Methods: We performed a prospective observational cohort study at Ain Shams University Maternity Hospital from January 2019 to December 2019 on 160 pregnant patients diagnosed with the placenta accreta spectrum. In all cases, parameters of complete blood count, including lymphocyte, platelet count, red cell distribution width (RDW), neutrophil/lymphocyte ratio, and mean platelet volume (MPV), were analyzed. Results: Among the patients studied, two subgroups were analyzed: placenta previa and placenta accreta. The results show a statistically significantly lower mean value of RDW and platelets in accreta than no accreta, with a p-value (<0.05), while a statistically significantly higher mean value of MPV and N/L ratio in accreta than no accreta, with p-value (<0.05). Receiver operator characteristics (ROC) curves showed that RDW%, Platelets, MPV, and N/L ratio indices were significant predictors as denoted by the significantly large area under the curves (AUC;0.668, 0.635, 0.780, and 0.696) and p-value (p<0.05) with MPV being the most significant predictor. Conclusions: CBC parameters are inexpensive, routinely feasible, and reproducible markers to help predict the Placenta accreta spectrum