Department of Pharmacology, College of Medicine, University of Al-Qadisiyah, Al Diwaniyah, Iraq
Research
The impact of metformin combined with spironolactone vs. metformin alone on adiponectin, ghrelin and hirsutism out comes females with PCOS
Author(s): Huda Ali Mohammed*, Asma Abdul JaleelSwadi and Sinaa Abdul Amir Kadhim
Background: Anovulation and hyperandrogenism, in combination with ovarian morphological changes, insulin resistance, inappropriate secretion of gonadotropins and associated compensatory hyperinsulinaemia, remain hallmarks of PCOS, a most common endocrine disease that afflicts some women. Three groups of patients were identified: the M group (n=50) receiving metformin, the MS group (n=50) receiving metformin and spironolactone, and the S group (n=50) receiving spironolactone. According to the Rotterdam guidelines (Rotterdam, 2004), two obstetricians and gynaecologists diagnosed these patients with Polycystic Ovarian Syndrome (PMS). The patients were enrolled as of the Maternity and Pediatrics Teaching Hospital in Adiwaniyah Province, Iraq. The training is to start after September 1, 2024 and will last until March 1, 2025. Results: All three treatment modalities, metformin, spironolacto.. Read More»