College of Pharmacy, Al-Esraa University, Karrada Street, Andalus Square, 10069, Baghdad, Iraq
Research
Metabolic outcomes in samples of PCOS reproductive aged Iraqi women reversed by oral combined metformin and spironolactone treatment
Author(s): Mustafa Mohammed Albassam*, Yasser Kadhim Hashem Al-Zwaini, Alaa Al-Noori, Mohammed Hasan Kadhim and Hilal Abdulla Younis
Background: One of the most critical parameters to diagnose Polycystic Ovarian Syndrome (PCOS) is prolactin (Pr), Follicle-Stimulating Hormone (FSH), Luteinizing Hormone (LH) and Luteinizing Hormone/Follicle- Stimulating Hormone (LH/FSH) ratio. Objective: Assess the clinical metabolic outcomes value of LH/FSH ratio, LH, FSH and Pr in productive-age women having polycystic ovarian syndrome after an average treatment period of three months with combined Metformin and Spironolactone. Design: A retrospective pilot study. Setting: Private Gynaecological Clinics, Baghdad, Iraq. Patients and methods: We selected reproductive-aged women with PCOS who underwent enzyme-linked immunosorbent assay tests of FSH, LH, and Pr before and after treatment. Women with hyperprolactinemia, thyroid disease, Cushing’s syndrome, and adrenal hyperplasia were excluded. We investigated patients, Pre-treatm.. Read More»