Abstract
Author(s): Sarah Itemad Abdul Sahib, Jinan M. J. Al-Saffar
Background: Polycystic ovarian syndrome (PCOS) is the most well-known endocrine condition among women, with 18- 27% prevalence. PCOS is a pro-inflammatory state, certain cytokines are correlated with women who have PCOS. Objective: The study aims to estimate the impact of some inflammatory mediators like CRP and interleukin 22 (IL-22) and interleukin 35 (IL-35) on PCOS. Methods: Eighty women, ranging in age from nineteen to forty, were part of the study; thirty of these women had polycystic ovarian syndrome, and thirty of these women had delayed childbearing. The other twenty women were healthy. We analyzed the CRP, IL-35, and IL-22 levels, after separating the serum by the ELISA method. Results: The results showed a decrease in CRP, IL-22 and IL-35 in patients with PCOS and in delayed childbirth women. Conclusion: In PCOS, we notice an imbalance in inflammatory indicators such as CRP, IL-22 and IL-35, and in women who have delayed childbearing.