gynecology and obstetrics medical project, gynecology journal, obstetrics, gynecologic oncology, reproductive medicine, gynecological endoscopy, ultrasonography, gynecology articles

Ginekologia i Poloznictwo
ISSN 1896-3315 e-ISSN 1898-0759

Effect of vitamin D oral supplementation in women with clomiphene citrate resistant polycystic ovarian syndrome (A one-arm clinical trial)


Author(s): Al Hassan Mohammad Khedr, Rana Alaa Eldin*, Hesham Harb and Laila Aly Farid

Background: Some data suggested that vitamin D ameliorates responsiveness to clomiphene citrate (CC) in women with polycystic ovary syndrome (PCOS). Aims: To assess the effect of oral supplement of vitamin D in patients with CC-resistant PCOS.

Subjects and methods: This was conducted in infertility clinic in Ain Shams Maternity Hospital including 130 women who were diagnosed as having PCOS: age of 18 to 37, body mass index of 25 to 35, being CC-resistant (failure to ovulate with 3 months of usage of CC at 150 mg /day for 5 days). The duration of the study ranged from 12 months, Results: As regard to ovulation-post-treatment, 29 (29%) patients could ovulate. As regard to pregnancy rate, 12 (12%) patients were positive and 88 (88%) patients were negative.

Conclusion: We cannot conclude whether this treatment actually improved pregnancy rate; however, some fraction of CC “resistant” women became “responsive”. Controlled study is needed to confirm the result.