gynecology and obstetrics medical project, gynecology journal, obstetrics, gynecologic oncology, reproductive medicine, gynecological endoscopy, ultrasonography, gynecology articles

Ginekologia i Poloznictwo
ISSN 1896-3315 e-ISSN 1898-0759

Correlation between serum vitamin D3 level and incidence of uterine leiomyoma in Egyptian women: An observational case-control study


Author(s): Mortada E. Ahmed, Magdy H. Kolaib, Aliaa M. Maaty, Mohamed S. Tolis* and Rania G. El-skaan

Background: Uterine fibroid is thought to be linked to Vitamin D insufficiency.

Objective: To explore the relationship between serum Vitamin D3 levels and uterine fibroids in Egyptian women seeking gynecological services.

Methods: This study was a case-control study conducted at Ain Shams University Maternity Hospital, Gynecology Department during the period from April 2021 to October 2021 on 80 women. Study populations were categorized into 2 groups; the fibroid group included 40 cases having uterine leiomyoma, as well as the control group of 40 cases who were leiomyoma-free women based on transvaginal ultrasound.

Results: While comparing women with uterine fibroids (UFs) to controls, vitamin D levels were significantly lower. (14.80 ± 5.87 vs 23.39 ± 9.11, P <0.001*). The deficiency condition (<20) was more common among the fibroid group than the control (77.5% VS 42.5%, respectively). In the fibroid group (22 %), the proportion of women in the insufficiency range (21–29) was lower than in the control group (25 %). The sufficient condition (30-100) was more common among controls. No case among the fibroid group had a normal vitamin D level. There was no significant relationship between vitamin D level (deficient and insufficient) and age, parity, hemoglobin, body mass index (BMI), size and number of fibroids, complaints, previous intervention, family, and associated gynecological diseases (p >0.05).

Conclusion: Although uterine leiomyomas are more prevalent among Egyptian women with D vitamin deficiency, no association between the vitamin D levels whether it was deficient or insufficient, and UL size and numbers were reported.