Ginekologia i Położnictwo medical project
ISSN 1896-3315 e-ISSN 1898-0759

Comparison between agonist trigger with HCG luteal phase supplementation vs. HCG trigger with progesterone luteal phase supplementation in antagonist controlled hyperstimulation cycle regarding clinical pregnancy rate


Abstract

Author(s): Maii Nawara*, Alaa El Din El Guindy, Walid Hitler, Sherif Yehia and Laila Aly Farid

Objective: We compared agonist trigger and HCG luteal support vs. standard HCG trigger and progesterone luteal supplementation in antagonist controlled hyperstimulation cycle as regards to clinical pregnancy rate.

Patients and Methods: The study was conducted on 100 women undergoing IVF treatment. They were randomized through a computer-generated list into two groups. Group I (n=50): Standard protocol HCG trigger with progesterone luteal support, and Group II (n=50): New protocol agonist trigger with HCG luteal support.

Results: Group II, compared with Group I, showed non-significant higher pregnancy rate. Group II showed much better compliance from patients: this was considered owing to the progesterone injection being administered intramuscularly or subcutaneously.

Conclusion: Low dose HCG luteal phase support with agonist trigger in antagonist cycles provided similar or higher (non-significant) pregnancy rates, compared with conventional HCG trigger and progesterone luteal phase support. This protocol provided better patient satisfaction and compliance.