Objective: We compared agonist trigger and HCG luteal support vs. standard HCG trigger and progesterone luteal supplementation in antagonist controlled hyperstimulation cycle as regards to clinical pregnancy rate.
Patients and Methods: The study was conducted on 100 women undergoing IVF treatment. They were randomized through a computer-generated list into two groups. Group I (n=50): Standard protocol HCG trigger with progesterone luteal support, and Group II (n=50): New protocol agonist trigger with HCG luteal support.
Results: Group II, compared with Group I, showed non-significant higher pregnancy rate. Group II showed much better compliance from patients: this was considered owing to the progesterone injection being administered intramuscularly or subcutaneously.
Conclusion: Low dose HCG luteal phase support with agonist trigger in antagonist cycles provided similar or higher (non-significant) pregnancy rates, compared with conventional HCG trigger and progesterone luteal phase support. This protocol provided better patient satisfaction and compliance.