Abstract
Author(s): Dariusz Kowalczyk, Wojciech Guzikowski, Jacek WiÄcek, Damian ZiÄtek
Introduction. Since 2005, was brought in Gynaecological and Obstetrical Hospital in Opole prenatal testing program, which aims at early detection of congenital defects in fetuses with the introduction of routine non-invasive diagnostic and / or invasive prenatal testing in pregnant women from the Opole area. Absolute indications for the implementation of invasive prenatal tests exist in high-risk group (age above 35 years of age, chromosomal aberrations on the fetus in previous pregnancies, being balanced translocation) In the group of women younger indication amniocentesis determined on the basis of incorrect test results PAPPA and triple and changes detected during ultrasound. The aim. The aim of this work was to evaluate the results since 2005 introduced the pre-natal examinations at Opole region. Materials and methods. Research and genetic counseling was covered by 758 women with highrisk groups. As part of the prenatal care program in each of the women started from the performance of diagnosis in the period from 10 to 13 weeks of pregnancy microchip ultrasound (CRL assessment, NT, NB and flows in the venous) and biochemical test PAPP-A to invasive prenatal tests (in amniocentesis 14-18 weeks of pregnancy) have been put on the basis of noninvasive abnormalities in 108 patients. Aminotic liquid collected in a hospital 99 women, 15 women has expressed consent to amniocentesis, in 2 cases, death was pregnant at the time the implementation of invasive tests. Results. Cytogenetic analysis of fetal cells 99 showed: 6 cases of trisomy chromosome 21, chromosome 1 case of trisomy 18, 1 case team 47, XXX and one case of acranius fetal. A statistically significant correlation between the value of NT in fetuses with normal and abnormal cariotype, at p = 0, 000 In contrast, was low statistically significant relationship between the B-HCG and PAPP-A between the two fetuses. There was no relationship between the time of termination of pregnancy, and the mass born in fetal Apgar scores of mothers, who are continuing amniocentesis and mothers, who have not performed amniocentesis. Invasive believe our study is a relatively safe method of determining cariotape the fetus in high-risk pregnancy genetic and do not involve any major complications immediately after and did not affect the time of pregnancy, weight born fetus as well as an assessment by the Apgar scale.