Ginekologia i Położnictwo medical project
ISSN 1896-3315 e-ISSN 1898-0759

Pregnancy outcomes improvement using intrauterine injection of hCG before ET in ICSI cycles


Author(s): Ahmed Tharwat Abo Dakika* and Hesham Ali Ammar

Background: Infertility affects about one in six to seven couples globally. Although ARTs (assisted reproductive technologies) have improved, the pregnancy rate is still not sufficient.

Objective: to determine the pregnancy outcomes improvement using Intrauterine Injection of hCG (human chorionic gonadotropin) before ET (embryo transfer) in ICSI Cycles.

Patient and methods: A total of 100 infertile women included in randomized control study which conducted at Repro fertility centre, Alexandria, Egypt, during March 2021 till April 2022, all included women were classified in to, group (I) included 50 infertile women received injection of 500 IU of intrauterine HCG 5 min before embryo transfer (ET) and group (II) included 50 infertile women who did not receive hCG. Demographic data, oocyte performance and pregnancy rate were taken for all studied women.

Results: number of fertilized oocytes was significantly increased among cases group (8.60 ± 2.72) than control group (7.60 ± 2.22), (P=0.047). Also, positive pregnancy test was the most popular among the studied groups 60(60%), with a significant difference (P<0.001). While, there were no significantly differences among the studied groups regarding number mature oocytes, number of retrieved oocytes and number of embryos transferred.

Conclusion: Our research suggested that HCG may enhance and improve endometrial receptivity, hence increasing pregnancy rates and implantation rates. HCG administered intrauterinelly had no effect on the likelihood of ovarian hyper-stimulation syndrome or the rate of first-trimester miscarriage. However, the data also brought up another issue that is crucial to the application of ART: an increase in the rate of multiple pregnancies.