Abstract
Author(s): HURAS HUBERT, WÃJTOWICZ ANNA, RADOÅ-POKRACKA MAÅGORZATA,STETTNER DOMINIKA, REROÅ ALFRED, RYTLEWSKI KRZYSZTOF, JACH ROBERT
Introduction. Preterm rupture of membranes is one of factors leading to preterm delivery. Proper function of the amniotic sac depends on stability of extracellular matrix, integrity of which relies on metalloproteinases and a tissue inhibitor - metalloprotein. Metalloproteinase activity is affected by inflammatory markers, hormones, growth factors and reactive oxygen species. Objective. The study focused on assessment of selected oxidative stress markers in women giving a preterm birth according to the PROM mechanism, compared to women giving birth on time Material and methods. Forty pregnant women giving a preterm birth according to the PROM mechanism and a control group of 40 pregnant women giving an on-term birth in the Department of Obstetrics and Perinatology of the Jagiellonian University Collegium Medicum between January 1st and December 30th 2009 were included in the study. The following compounds were determined in blood serum collected from patients belonging to both groups in order to analyse selected parameters of oxidative stress: superoxide dismutase (SOD), myeloperoxidase (MPO), malonic aldehyde (MDA), glutathione reductase (GR), glutathione peroxidase (GPx), total antioxidant status of plasma (TAS). The above mentioned determinations were performed once, during childbirth. Results. In the analysed groups the levels of superoxide dismutase, myeloperxidase, malonic aldehyde, glutathione reductase and glutathione peroxidise were higher in the study group compared to the control. An opposite observation was made for total antioxidant status