Author(s): Leszek Nowak (AEF), Katarzyna Olszak-W?sik (EF), Anita Olejek (E)
Wound healing is a complex process with the inflammatory phase being one of its stages, followed by tissue re-shaping and remodeling. Kinins are active peptides released from their precursors, kininogens, by kallikreins. Their action is multidirectional and includes, e.g. modulation of inflammation severity and regulation of cell proliferation. They are local hormonal factors and act via the bradykinin receptors BR1 and BR2. Owing to the broad spectrum of action, kinins will probably enable treatment of various diseases in the future. Increased expression of type 1 bradykinin receptors is observed in chronic inflammation, whereas type 2 bradykinin receptors are activated in both physiological states and acute inflammation. An imbalance between the expression profiles of B1 and B2 receptors may be an indicator of chronic inflammation and of their role in cell proliferative activity. The transcriptional activity of genes encoding B1 and B2 kinin receptors may be a criterion in the prognosis of postoperative wound healing, thereby enabling its monitoring and individualization of treatment.