Author(s): BEATA MARCINIAK, ANNA MICHAÅOWSKA, DARIUSZ SZYMULA, JOLANTA PATRO-MAÅYSZA, JAN OLESZCZUK, BOÅ»ENA LESZCZYÅSKA-GORZELAK
Intrahepatic Cholestasis of Pregnancy (ICP) is the most common liver disorder in pregnancy; it occurs mainly in the third trimester of pregnancy and characterized by pruritus and abnormal liver function. This disease usually poses no threat to the pregnant woman, however, because of the risk to the fetus (preterm delivery, asphyxial events and even intrauterine death), it becomes a serious clinical problem marred by adverse antenatal outcomes. Etiology and pathogenesis of the disease is not fully explained. Current researches focus on genetic and hormonal dysfunctions. Treatment is primarily symptomatic. It seems that ursodeoxycholic acid (UDCA) is now the most promising and effective method of treatment, but so far the perfect way of fetal surveillance has not been found.