Author(s): Ahmed Gamal Abdelnasser, Mohamed Taha Ismail Mahmoud, Dalia Ali Mohamed Hassen*, Mohamed Gamaleldin Lotfy Fouly, Mai Medhat Nawara
Background: Obesity is a chronic disease influenced by many factors. It is a significant public health issue worldwide, particularly in Western countries where its prevalence is consistently increasing. Obesity is a major risk factor for various chronic illnesses, including cancer. Aim of the work: This study aims to assess the effect of weight loss caused by bariatric surgery on female fertility. Methods: This prospective cohort study was conducted at Ain Shams University Hospitals (ASUH) from June 2022 to December 2022. It involved 75 obese women who underwent bariatric surgery (sleeve gastrectomy) at ASUH. Results: The BMI of the patients who underwent surgery significantly decreased in the three months after the operation. Additionally, there was a significant loss of excess body weight, with an average of more than a quarter of the excess weight at 29.9 ± 6.6%. The patients' levels of AMH, LH, and FSH/LH also significantly decreased three months after the surgery. However, FSH levels significantly increased at the same time point. Furthermore, there was a significant positive correlation between the BMI at three months and the levels of postoperative AMH and LH. Conversely, there was a significant negative correlation between the BMI at three months and the postoperative FSH/LH levels. Conclusion: Bariatric surgery can help improve reproductive hormones and menstruation in severely obese women. We found that levels of AMH and LH decrease while FSH increases, leading to improved menstrual cycle regularity.