Author(s): Tomasz G?ca, Agnieszka Martyniuk-G?ca
IGFBP-2 as part of theinsulin-like growth factor system has so far generatedsubstantial interest among researchers due to its participation in the process of carcinogenesis. At present,its vital role in maintaining proper carbohydrate management is frequently emphasized. The most common metabolic complication in pregnancy is gestational diabetes mellitus,during which carbohydrate tolerance is disturbed. Changes in IGFBP- 2 concentration in GDM areobserved as early as in the first trimester of pregnancy, which proves the significant role of this protein in the pathogenesis of GDM.