Author(s): Ewa Rudnicka, Waldemar Wierzba, Stanis?aw Radowicki
Introduction. Aim. To evaluate hormonal profile among women with androgen excess disorders depending on menstrual pattern. Material and methods. The material were 231 patients aged 18-35 years (mean 25,46 ± 4,36) who were hospitalized in the Gynaecologic Endocrinology Department of Warsaw Medical University due to hyperandrogenic syndrome in the years 2003-2005. In every patient the fallowing hormone levels were analyzed: FSH, LH, E2, PRL, testosterone, androstendione, 17αhydroksyprogesterone, dehydroepi-androsterone and progesterone. The patients were divided into four groups depending on menstrual pattern: polymenorrhoea (n=32), oligomenorrhoea (n=93), normal menstrual pattern (n=66) and secondary amenorrhoea (n=40). The control group consisted of 40 healthy women with normal menstrual cycles and no symptoms of hyperandrogenism. Statistic analysis was performed using chi-square, Anova and NIR tests. Volues of p<0,05 were assumend to be significant. Results. No statistic signifficance was found between the patient’s age, menarche age and BMI in women. There was a significant difference between all study groups and the control group in the fallowing hormone concentrations: LH, testosterone, PRL, androstendione, 17α-OHP and progesterone. No statistic significance was found in the remaining hormones concentrations. Conclusions. Hormonal profile in patients with hyperandrogenic syndrome varies depending on menstrual cycle. With the increase of androgens and LH level, the menstrual cycle extends. The highest androgens serum levels were observed in secondary amenorrhoea patients. In those patients we also observed the lowest progesterone serum levels.