gynecology and obstetrics medical project, gynecology journal, obstetrics, gynecologic oncology, reproductive medicine, gynecological endoscopy, ultrasonography, gynecology articles

Ginekologia i Poloznictwo
ISSN 1896-3315 e-ISSN 1898-0759

GnRH agonist trigger vs. HCG trigger for tinal oocyte maturation in GnRH antagonist protocol ICSI cycles: A randomized controlled trial


Author(s): Marwa Saber Snosi, Mohamed Hussein Mostafa, Mounir Alam Eldin and Ahmed Sherif Abdel Hamid*

Background: Infertility is common and the global burden remains high over years. With the explosive increase In Vitro Fertilization (IVF) cycles worldwide, the morbidity and mortality associated with Ovarian Hyper Stimulation Syndrome (OHSS) cannot be ignored. Clinicians all over the world are moving toward newer modifications to eliminate its occurrence.

Objective: To compare the effectiveness of GnRHa versus HCG trigger to reduce OHSS. Patients and methods: 200 women who underwent ICSI at Ain Shams university hospital IVF center and other private center using GNRH long antagonist protocol; were randomly divided into two equal groups 1st group 100 cases received agonist trigger with cycle segmentation and the other group 100 cases received Human Chorionic Gonadotropin (HCG) as trigger.

Results: There was a high statistically significant difference between GnRHa and HCG groups as regard OHSS rate, with higher percentage of cases among HCG group (3% vs. 20%). p-value was <0.001.

Conclusion: Using GnRHa trigger has the advantage over HCG trigger regarding OHSS rate with lower incidence of OHSS rate among GnRHa group.