gynecology and obstetrics medical project, gynecology journal, obstetrics, gynecologic oncology, reproductive medicine, gynecological endoscopy, ultrasonography, gynecology articles

Ginekologia i Poloznictwo
ISSN 1896-3315 e-ISSN 1898-0759

Folic acid versus metafolin in Evidence Based Medicine



Polish Gynecological Society recommends the supplementation with 0.4mg of folic acid inpericonceptional period and the first trimester of pregnancy. 5-methyltetrahydrofolate and folicacid have similar biological activity, bioavailability and comparably reduce plasma homocy-steine concentration. 5-methyltetrahydrofolate more effectively increases plasma and red blo-od cell folate levels compared with folic acid. 5-methyltetrahydrofolate might constitute analternative form of folate supplementation. Research on the effect of 5-methyltetrahydrofolateand folic acid equimolar doses on the reduction level of neonatal neural tube defects areessential.

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