gynecology and obstetrics medical project, gynecology journal, obstetrics, gynecologic oncology, reproductive medicine, gynecological endoscopy, ultrasonography, gynecology articles

Ginekologia i Poloznictwo
ISSN 1896-3315 e-ISSN 1898-0759

Evaluation of immunological markers among women with recurrent abortion in Thi-Qar province


Abstract

Author(s): Widyan Gataa Washel*, Hassan Raysan Mobarak, Hind Muzhir Mousa

Many women around the world suffer from recurrent miscarriages associated with immune disorders Leading to decreased maternal and fetal tolerance. Thus, this study designed to evaluate the levels of Antiphospholipid antibodies (APL IgG & IgM and TGF-β1 in patients' women with recurrent abortions by using Enzyme-Linked Immune Sorbent Assay (ELISA). The current study included 100 women blood samples with recurrent miscarriage and 50 blood samples from apparently healthy women as control group their ages ranged between 17- 45 years. The results of the statistical analysis showed a significant increase in the levels of IgM, IgG and TGF-β1 in patients with recurrent miscarriage compared to the control group. Furthermore, highly significant positive strong correlation between IgM and IgG APL antibodies, and non-significant weak positive correlation between TGF-β and both antibodies (IgM and IgG APL) were indicated. In conclusion, TGF-β1 levels in miscarriage women are closely related to APLA levels during pregnancy and may have an influential role in pregnancy outcomes.