Author(s): ANNA BEDNARSKA-CZERWI?SKA1, DARIUSZ MERCIK1, MICHA? CZERWI?SKI2
This paper discusses significant elements that make up the decidualization of the endometriumwhich renders this tissue capable of embryo implantation, i.e. makes it receptive. Subsequ-ently, angiogenesis, penetration of the endometrium by macrophages, immune polarization andthe problem or maternal immune tolerance to the embryo are discussed. A significant elementfor effective implantation is the site where the apical layer of the decidua communicates withthe outer surfaces of the embryo. This communication is facilitated or prevented by adhesionmolecules present in the endometrium. Leukemia inhibitory factor (LIF) and its receptor areparticularly emphasized. Other markers mentioned in the paper are: mucin (MUC1), glyco-delin A, integrins, L-selectin, interleukins (IL-1 and IL-6), E-cadherin and cyclin. Finally,a search for genetic markers of endometrial receptivity and the role of HOXA-10 and HOXA-11 genes are presented.