gynecology and obstetrics medical project, gynecology journal, obstetrics, gynecologic oncology, reproductive medicine, gynecological endoscopy, ultrasonography, gynecology articles

Ginekologia i Poloznictwo
ISSN 1896-3315 e-ISSN 1898-0759

Efficacy of sequential embryo transfer in improving pregnancy rate in women with repeated unexplained implantation failure


Author(s): Mohammed Hussain Mostafa, Hussam M. Samir* and Marwa S. Sayed

Aim: In women with repeated IVF-failure, pregnancy rate was compared between sequential embryo transfer (ET: ET on day 3 and 5) vs. day 3 ET.

Patients and Methods: A randomized controlled clinical trial was conducted from September 2019 till September 2020 on 80 women with repeated

IVF-failure: sequential ET (n=40) vs. day 3 ET (n=40). Pregnancy outcomes were compared between the two groups.

Results: Sequential ET, compared with day 3 ET, showed higher chemical, clinical, and ongoing pregnancy, i.e., with sequential ET showing 37%, 35%, and 32.5%, respectively; and with day 3 ET showing 17.5%, 15%, and 12.5%, respectively.

Conclusion: For patients with repeated IVF-failures, sequential ET improved the chemical, clinical, and ongoing pregnancy rates as long as good quality embryos were available.