gynecology and obstetrics medical project, gynecology journal, obstetrics, gynecologic oncology, reproductive medicine, gynecological endoscopy, ultrasonography, gynecology articles

Ginekologia i Poloznictwo
ISSN 1896-3315 e-ISSN 1898-0759

Clinical usefulness of interleukin 1 alpha measurement in diagnostics of intraamniotic infection and newborn status in the group of pregnant women with premature rupture of membranes



Introduction. Premature rupture of membranes (PROM) is currently considered to be the main risk factor for intraamniotic infection (IAI).Aim of the study. To evaluate the usefulness of measurement of IL-1 alpha serum concentration at pregnant with PROM (premature rupture of membranes) in the retrospective diagnostics of IAI (intraamniotic infection), predicting time of pregnancy prolongation and newborn status. Material and methods. In serum of pregnant women with PROM IL-1 alpha concentration was measured. (ELISA). The relations between received values and the following parameters were examined: time from PROM to the childbirth, time from clinical examination to the birth, Apgar score, time of newborn hospitalization, inborn infection. Results. There was no statistically significant differences between the group, in which concentration of IL-l alpha was lower than 3.5 pg/ml, and the group, where IL-l alpha concentration was higher than 3.5 pg/ml as to the gestational age, time of pregnancy prolongation, time from PROM to the childbirth. In the reference to the newborn condition and inborn infection there was also no differences observed. Conclusion. The usefulness of IL-1 alpha concentration in the retrospective diagnostics of IAI at mothers of newborns with infection symptoms has not been stated. We have not indicated the usefulness of measurement of IL-1 alpha serum concentration at pregnant with PROM in prediction of pregnancy prolongation, newborn status after delivery and prediction of infections development at babies of mothers with PROM.