gynecology and obstetrics medical project, gynecology journal, obstetrics, gynecologic oncology, reproductive medicine, gynecological endoscopy, ultrasonography, gynecology articles

Ginekologia i Poloznictwo
ISSN 1896-3315 e-ISSN 1898-0759

Assessment of concentrations of heat shock protein Hsp60 in pregnant women with gestational hypertension in the third trimester of pregnancy and after childbirth



Introduction. Heat shock protein (Hsp) in the human body provides protection against cellularand environmental stress factors. Their primary role is to weaken the effects of stressors. Inconditions of cellular stress we observe the rapid increase in concentrations of Hsp in thecytoplasm and their transport, among others, to the nucleus, where it protects DNA, pre-mRNA,pre-ribosomes and nuclear proteins from degradation. Aim of the study. Evaluation of the clinical usefulness of the determination of the concentra-tions of heat shock protein Hsp60 in the following groups: healthy pregnant women, pregnantwomen with gestational hypertension in the third trimester of pregnancy and during labor andnon-pregnant women.Material and methods. The study included 64 women: 28 pregnant women with pregnancycomplicated by gestational hypertension, 16 healthy pregnant women and 20 healthy womenwho are not pregnant. The designation of the concentrations of heat shock proteins havinga molecular weight of 60 kDa (Hsp60) was performed with use of enzyme-linked immuno-sorbent assay (ELISA).Results. Average concentrations of Hsp60 proteins were statistically significantly different be-tween the start and end point of taking the sample for determination (III trimester of pregnan-cy vs. after delivery), both in the group of healthy pregnant women and in women withgestational hypertension. In both groups, the concentration of Hsp60 was significantly higherafter delivery. In addition, a highly statistically significant difference in the concentration ofHsp60 between the group of non-pregnant women and healthy pregnant group after deliverywas demonstrated, the concentration of Hsp60 was significantly higher after delivery.Conclusions. Pregnancy does not affect the concentration of the heat shock protein Hsp60.Delivery induces increased concentrations of heat shock proteins both in normal pregnancyand pregnancy complicated by hypertension.

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