gynecology and obstetrics medical project, gynecology journal, obstetrics, gynecologic oncology, reproductive medicine, gynecological endoscopy, ultrasonography, gynecology articles

Ginekologia i Poloznictwo
ISSN 1896-3315 e-ISSN 1898-0759

Arginine and citrulline and fetal hypotrophy ? part II


Abstract

Author(s): Agata Pardej, Marian Grybo?, Janusz Kubicki, Andrzej Gamian, Wojciech Guzikowski

Introduction. According to literature, good clinical results were obtained for trials of fetal hypotrophy treatment with exogenous L-arginine. Aim. The aim of the paper was to compare of arginine and citrulline (arginine’s metabolite in human body) concentrations in blood of pregnant women in cases of fetal hypotrophy treated with L-arginine with the group of healthy pregnant. Materials and methods. Control group - 24 women at III trimester of physiological pregnancy. Examined group – 29 women at III trimester of pregnancy with diagnosed fetal hypotrophy treated with L-arginine at a dose of 3g a day. Amino acids determination was performed by the method of HPLC. Results. Average concentration of arginine amounted to 108.79 µmol/l and citrulline to 61.59 µmol/l in group of healthy pregnant women. In group of women with hypotrophy arginine concentration amounted to 109.45 µmol/l and after the treatment it increased to 146.47 µmol/ l, while citrulline concentrations were found to achieve levels of 65.11 µmol/l and 155.33 µmol/ l, respectively. Conclusions. Arginine and citrulline concentrations in blood serum of pregnant women with fetal hypotrophy were on the level characteristic for women with physiological pregnancy. After treatment with L-arginine statistically significant increase of arginine and citrulline concentrations in blood serum of pregnant with hypotrophy occurred in comparison to the values obtained before the treatment and for control group

SCImago Journal & Country Rank
+447915608527